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FrameFlow × LTX: joint_vae

Research experiment adapting LTX-Video, especially Figure 4, to representations from vanilla FrameFlow. This is a protein adaptation, not a reproduction of the video model.

Training completed 419,933 optimizer updates: 2.000 VAE training hours and 12.000 latent-flow training hours. The codec is frozen and its latents calibrated on training examples before flow training.

W&B run.

Contents

All interval/final checkpoints with SHA-256 files; complete config; source snapshots and dependency locks; dataset/teacher provenance; per-example batch records; training and fixed-validation metrics; generated backbone mmCIF/NPZ files; final training plots and architecture diagram; local W&B run records. The frozen published initialization is under initialization/ for reproducibility. Training data are referenced by dataset revision/hash rather than duplicated.

Interpretation

Data: the corrected dense population of raftbioworks/train_A100_multimer_816, with the same PDB-entry holdout as the preceding FrameFlow experiments. This split is not homology-disjoint and may overlap the teacher's original pretraining population. Whole assemblies are used without length crops. Geometry and canonical-frame reconstruction are diagnostic metrics, not evidence of foldability. Generated ALA sequences are placeholders. No sequence design, refolding or wet-lab validation is claimed. The four conditions have equal duration targets but different throughput and token counts; use the recorded steps, examples, hardware, and training time when comparing them.

Attribution and license

Published FrameFlow weights are CC BY 4.0 (https://zenodo.org/records/12776473). FrameFlow code is MIT; shared FrameDiff/OpenFold components retain their upstream licenses. See source snapshots and project documentation for the exact protein mappings and ablation switches. The LTX paper PDF and private credentials/caches are not redistributed.

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